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PGP Participant Survey
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Responses submitted 12/23/2013 21:06:37.
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| Timestamp |
12/23/2013 21:06:37 |
| Year of birth |
1964 |
| Do you have a severe genetic disease or rare genetic trait? If so, you can add a description for your public profile. |
I have had metaplastic carcinoma of the breast twice. Once in 2/12 and once in 2/13. This is a very rare breast cancer. I am BRCA1&2 negative and also have had the BROCA test with no known mutations detected.
The first tumor was:
Low grad spindle cell metaplastic carcinoma arising from a sclerosed papilloma with and in situ squamous cell carcinoma component.
The second tumor was:
Microscopic examination reveals a malignant neoplasm, characterized by intermediate to high nuclear grade cellular proliferation. The tumor cells are predominantly spindle in shape and are focally arranged in short fascicles. In other areas they line irregular spaces leading to a pseudoangiosacromatous appearance. Immunohistochemical studies demonstrate strong immunoreactivity with cytokerartins CK AE1/3, CAM 5.2, CK 34BE12, CK 5/6 and p63 in the later areas and only focal staining in the spindle cell areas. The tumor cells are also strongly positive for vimentin, and negative for s-100, CD34 and SMA.
Proliferation index (Ki-67) is positive, 22% nuclear staining (Unfavorable).
Ki67 clone MIB (Dako).
The morphologic features and the IHC results are consistent with metaplastic carcinoma with areas of spindle cell carcinoma and squamous cell carcinoma, acantolythic viariant.
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| Sex/Gender |
Female |
| Race/ethnicity |
White |
| Maternal grandmother: Country of origin |
United States |
| Paternal grandmother: Country of origin |
United States |
| Paternal grandfather: Country of origin |
United States |
| Maternal grandfather: Country of origin |
United States |
| Month of birth |
September |
| Anatomical sex at birth |
Female |
| Maternal grandmother: Race/ethnicity |
White |
| Maternal grandfather: Race/ethnicity |
White |
| Paternal grandmother: Race/ethnicity |
White |
| Paternal grandfather: Race/ethnicity |
White |
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PGP Trait & Disease Survey 2012: Cancers
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Responses submitted 12/23/2013 21:07:48.
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| Timestamp |
12/23/2013 21:07:48 |
| Have you ever been diagnosed with one of the following conditions? |
Breast cancer, Breast fibroadenoma, Uterine fibroids |
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PGP Trait & Disease Survey 2012: Endocrine, Metabolic, Nutritional, and Immunity
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Responses submitted 12/23/2013 21:08:46.
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| Timestamp |
12/23/2013 21:08:46 |
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PGP Trait & Disease Survey 2012: Blood
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Responses submitted 12/23/2013 21:09:41.
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| Timestamp |
12/23/2013 21:09:41 |
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PGP Trait & Disease Survey 2012: Nervous System
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Responses submitted 12/23/2013 21:12:41.
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| Timestamp |
12/23/2013 21:12:41 |
| Other condition not listed here? |
When I was young I used to have Recurrent sleep paralysis but was not diagnosed with this and have not had it in years |
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PGP Trait & Disease Survey 2012: Vision and hearing
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Responses submitted 12/23/2013 21:15:31.
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| Timestamp |
12/23/2013 21:15:31 |
| Have you ever been diagnosed with one of the following conditions? |
Hyperopia (Farsightedness) |
| Other condition not listed here? |
age and chemo related issues with sight that is corrected by reading glasses |
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PGP Trait & Disease Survey 2012: Circulatory System
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Responses submitted 12/23/2013 21:17:03.
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| Timestamp |
12/23/2013 21:17:03 |
| Have you ever been diagnosed with one of the following conditions? |
Premature ventricular contractions, Hemorrhoids |
| Other condition not listed here? |
PVC' started post chemo |
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PGP Trait & Disease Survey 2012: Circulatory System
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Responses submitted 12/23/2013 21:17:57.
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| Timestamp |
12/23/2013 21:17:57 |
| Have you ever been diagnosed with one of the following conditions? |
Premature ventricular contractions, Hemorrhoids |
| Other condition not listed here? |
PVC's began post chemo |
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PGP Trait & Disease Survey 2012: Respiratory System
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Responses submitted 12/23/2013 21:18:49.
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| Timestamp |
12/23/2013 21:18:49 |
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PGP Trait & Disease Survey 2012: Digestive System
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Responses submitted 12/23/2013 21:19:58.
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| Timestamp |
12/23/2013 21:19:58 |
| Have you ever been diagnosed with any of the following conditions? |
Canker sores (oral ulcers), Gallstones |
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PGP Trait & Disease Survey 2012: Genitourinary Systems
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Responses submitted 12/23/2013 21:21:23.
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| Timestamp |
12/23/2013 21:21:23 |
| Have you ever been diagnosed with any of the following conditions? |
Urinary tract infection (UTI), Fibrocystic breast disease, Ovarian cysts |
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PGP Trait & Disease Survey 2012: Skin and Subcutaneous Tissue
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Responses submitted 12/23/2013 21:22:33.
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| Timestamp |
12/23/2013 21:22:33 |
| Have you ever been diagnosed with any of the following conditions? |
Eczema, Allergic contact dermatitis, Acne |
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PGP Trait & Disease Survey 2012: Musculoskeletal System and Connective Tissue
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Responses submitted 12/23/2013 21:23:46.
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| Timestamp |
12/23/2013 21:23:46 |
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PGP Trait & Disease Survey 2012: Congenital Traits and Anomalies
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Responses submitted 12/23/2013 21:25:31.
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| Timestamp |
12/23/2013 21:25:31 |
