23andMe Established Research Reports 

Ellen Bronder - August 3, 2011 

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Intended for research and educational purposes. Not for diagnostic use. 

Drug Response: Response to Hepatitis C Treatment 

Moderately lower odds of responding to PEG-IFNalpha/RBV treatment for hepatitis C. 

23andMe Name Genotype 

rs8099917 GT 

Drug Response: Pseudocholinesterase Deficiency 

One copy of one of the BCHE mutations reported by 23andMe. Increased risk for slightly extended paralysis and 
apnea after treatment with choline ester drugs. 

23andMe Name Other Name(s) DNA Change Genotype 

rs1799807 Asp70Gly (A) T to C CT (variant present) 
rs28933389 Thr243Met (F1) G to A GG 
rs28933390 Gly390Val (F2) C to A CC 

Only a medical professional can determine the right medication for a particular patient. This information should not be used to 
independently establish or adjust an existing regimen. 

Disease Risk: Age-related Macular Degeneration 

27 out of 100 women of European ethnicity who share this genotype will get Age-related Macular Degeneration 
between the ages of 43 and 79. The average for this population is 7.0 out of 100. 

Gene or Region SNP Genotype Adjusted Odds Ratio 
CFH rs1061147 AA 2.77 
C2 rs547154 GG 1.07 
LOC387715/ARMS2 rs3750847 CT 1.63 

Disease Risk: Ulcerative Colitis 

0.7 out of 100 women of European ethnicity who share this genotype will get Ulcerative Colitis between the ages of 0 
and 79. The average for this population is 0.5 out of 100. 
Gene or Region SNP Genotype Adjusted Odds Ratio 
HLA-DRA rs2395185 GG 1.33 
BSN rs9858542 AG 1.03 
NKX2-3 rs10883365 AG 0.98 
IL23R rs11209026 GG 1.06 

Copyright © 23andMe, Inc. All rights reserved. 23andMe is a genetic testing service that provides information and tools to understand your DNA. 


23andMe Established Research Reports 

Ellen Bronder - August 3, 2011 

Disease Risk: Primary Biliary Cirrhosis 

0.4 out of 100 women of European ethnicity who share this genotype will get Primary Biliary Cirrhosis between the 
ages of 20 and 79. The average for this population is 0.3 out of 100. 
Gene or Region SNP Genotype Adjusted Odds Ratio 
IRF5 rs10488631 TT 0.83 
IL12A rs574808 TT 1.26 
SPIB rs3745516 AG 1.19 

Disease Risk: Bipolar Disorder 

0.2 out of 100 women of European ethnicity who share this genotype will get Bipolar Disorder between the ages of 16 
and 79. The average for this population is 0.1 out of 100. 
Gene or Region SNP Genotype Adjusted Odds Ratio 

10q21 rs4948418 CT 1.45 

Disease Risk: Esophageal Squamous Cell Carcinoma (ESCC) 

0.09 out of 100 women of Asian ethnicity who share this genotype will get Esophageal Squamous Cell Carcinoma 
(ESCC) between the ages of 30 and 79. The average for this population is 0.07 out of 100. 
Gene or Region SNP Genotype Adjusted Odds Ratio 

PLCE1 rs2274223 AG 1.21 

Disease Risk: Stomach Cancer (Gastric Cardia Adenocarcinoma) 

0.08 out of 100 women of Asian ethnicity who share this genotype will get Stomach Cancer (Gastric Cardia 
Adenocarcinoma) between the ages of 25 and 79. The average for this population is 0.07 out of 100. 
Gene or Region SNP Genotype Adjusted Odds Ratio 

PLCE1 rs2274223 AG 1.22 

Copyright © 23andMe, Inc. All rights reserved. 23andMe is a genetic testing service that provides information and tools to understand your DNA.